阿霉素
药物输送
纳米载体
纳米技术
自愈水凝胶
毒品携带者
纳米凝胶
药理学
微粒
控制释放
靶向给药
化学
材料科学
抗癌药
输送系统
计算机科学
体内
盐酸阿霉素
生物相容性
医学
化疗
外科
有机化学
物理
光学
作者
Jaya Lakkakula,Pratik Gujarathi,Prachi Pansare,Swastika Tripathi
标识
DOI:10.1016/j.carbpol.2021.117696
摘要
Doxorubicin (DOX), an anthracycline drug, is widely used for the treatment of several cancers like osteosarcoma, cervical carcinoma, breast cancer, etc. DOX lacks target specificity; thereby it also affects normal cells thus resulting in several side-effects. A drug delivery system (DDS) can be used to deliver the drug in a controlled and sustained manner at a targeted site within the body. Various DDS like nanoemulsions, polymeric nanoparticles, and liposomes are used for loading DOX. Alginate, a polysaccharide is widely used for fabricating DDS due to its biodegradable and bio-compatible properties. Alginates, in combination with other biomaterials, have been extensively used as a novel drug delivery carrier for DOX. Alginate provides a platform for drug delivery in different forms like hydrogels, nanogels, nanoparticles, microparticles, graphene oxide systems, magnetic systems, etc. Herein, we briefly describe alginate in combination with other materials as a nanocarrier for targeted delivery of DOX for anti-cancer treatment.
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