医学
妊娠胆汁淤积症
胃肠病学
内科学
胆汁酸
接收机工作特性
怀孕
体质指数
天冬氨酸转氨酶
胎儿
碱性磷酸酶
酶
遗传学
生物化学
生物
化学
作者
Harun Egemen Tolunay,Neval Çayönü Kahraman,Erol Nadi Varlı,Seval Yılmaz Ergani,Mehmet Obut,Şevki Çelen,Ali Turhan Çağlar,Yaprak Engin Üstün
标识
DOI:10.1016/j.ejogrb.2020.11.014
摘要
Abstract
Objective
To evaluate the predictive value of the first-trimester aspartate aminotransferase (AST)/platelet count ratio [AST to platelet ratio index (APRI) score] for intrahepatic cholestasis in pregnancy (ICP). Methods
This study consisted of a patient group diagnosed with ICP (n = 37) and a control group (n = 66) who presented to the hospital perinatology clinic between 2018 and 2020. Laboratory tests of both groups were analysed retrospectively. Age, gravida, parity, body mass index, third-trimester laboratory tests and first-trimester APRI scores were compared between the two groups. A receiver operating characteristic (ROC) analysis of the study was performed to determine the cut-off value for APRI score that is predictive of ICP. Results
Patients with ICP had significantly higher first-trimester APRI scores compared with controls (p < 0.001). In the ROC analysis, the cut-off value for APRI score was 0.57, with 86.5 % sensitivity and 77.3 % specificity. Spearman's correlation indicated that there was a significant positive association between first-trimester APRI score and third-trimester fasting bile acid level (r = 0.641, p < 0.001). The demographic characteristics of patients in the third trimester did not differ, except for AST and alanine transferase values. Conclusions
The APRI score calculated in the first trimester of pregnancy seems to be predictive of the development of ICP in the third trimester.
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