三萜类
赫拉
化学
传统医学
IC50型
体外
立体化学
癌细胞系
植物
生物
癌细胞
生物化学
癌症
医学
遗传学
作者
Yin-Hua Deng,Sha Zhang,Wei Hu,Wei Wu,Chunmao Dong,Fenghua Kang,Wen‐Xuan Wang,Dekun Chen,Kang‐Ping Xu,Zhen‐Xing Zou
标识
DOI:10.1080/10286020.2020.1779708
摘要
One new pentacyclic triterpenoid, urs-12,16-dien-3-one (1), together with twelve known pentacyclic triterpenoids (2‒13), were isolated from the twigs and leaves of Melaleuca linariifolia. Their structures were characterized by their 1D- and 2 D-NMR spectra analysis and mass spectra studies. Furthermore, all isolated compounds were tested the inhibitory effect on proliferation of six human cancer cell lines in vitro, including NCI-H441, NCI-H460, A549, SKOV3, hela, and caki-1 cells. Among them, compounds 3, 5, 7, 9, 12, and 13 exhibited moderate antiproliferative activities with IC50 values ranging from 3.85 to 33.31 μM.
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