医学
发病机制
破骨细胞
内科学
内分泌学
免疫学
骨吸收
单核细胞
作者
Anna Kloska,Anna Korzon-Burakowska,Marcelina Malinowska,Bożena Bruhn-Olszewska,Magdalena Gabig-Cimińska,Joanna Jakóbkiewicz-Banecka
标识
DOI:10.1016/j.diabres.2020.108337
摘要
Charcot neuroarthropathy is a chronic, progressive condition of the skeletal system that affects some patients with diabetic neuropathy. It results in progressive destruction of bones of the foot and disorganisation of pedal joints and ligaments. Effective prevention and treatment for Charcot neuroarthropathy remain a challenge. Currently, there are no reliable repeatable markers to identify patients with diabetes who are at higher risk of developing Charcot neuroarthropathy. The pathogenesis underlying the development of Charcot neuroarthropathy also remains unclear. In this review, we provide an overview of the history, prevalence, symptoms, risk factors, diagnostics and treatment of Charcot neuroarthropathy. We also discuss the potential for OPG and RANKL gene variants to act as predictive markers for the development of Charcot neuroarthropathy. Finally, we summarise the latest research on the role of monocyte-to-osteoclast differentiation in the development of acute Charcot neuroarthropathy.
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