This chapter deals with a miscellaneous group of astrocytoma variant lesions. Some of the more distinctive variants are separately dealt with in other chapters, including the pilocytic astrocytoma (Chapter 7), pleomorphic xanthoastrocytoma (Chapter 8), and subependymal giant cell astrocytoma (Chapter 9). This chapter will focus on four particular astrocytoma variants including the gemistocytic astrocytoma, protoplasmic astrocytoma, infantile desmoplastic astrocytoma, and the gliofibroma.