收缩性
心室
医学
心肌梗塞
体内
心脏病学
心功能曲线
内科学
心肌
生物医学工程
梗塞
作者
Marcelo Muñoz,Cagla Eren Cimenci,Keshav Goel,Maxime Comtois-Bona,Mahir Hossain,Christopher D. McTiernan,Matias Zuñiga-Bustos,Alex Ross,Brenda Truong,Darryl R. Davis,Wenbin Liang,Benjamin H. Rotstein,Marc Ruel,Horacio Poblete,Erik J. Suuronen,Emilio I. Alarcon
出处
期刊:ACS Nano
[American Chemical Society]
日期:2022-02-14
标识
DOI:10.1021/acsnano.1c08890
摘要
We report the development, as well as the in vitro and in vivo testing, of a sprayable nanotherapeutic that uses surface engineered custom-designed multiarmed peptide grafted nanogold for on-the-spot coating of an infarcted myocardial surface. When applied to mouse hearts, 1 week after infarction, the spray-on treatment resulted in an increase in cardiac function (2.4-fold), muscle contractility, and myocardial electrical conductivity. The applied nanogold remained at the treatment site 28 days postapplication with no off-target organ infiltration. Further, the infarct size in the mice that received treatment was found to be <10% of the total left ventricle area, while the number of blood vessels, prohealing macrophages, and cardiomyocytes increased to levels comparable to that of a healthy animal. Our cumulative data suggest that the therapeutic action of our spray-on nanotherapeutic is highly effective, and in practice, its application is simpler than other regenerative approaches for treating an infarcted heart.
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