骨髓炎
金黄色葡萄球菌
炎症
成骨细胞
细胞因子
医学
骨感染
免疫学
骨重建
癌症研究
化学
生物
内科学
细菌
体外
遗传学
生物化学
作者
Chaolai Jiang,Yiwei Lin,Haojie Shan,Wenwen Xia,Cunhong Pan,Nan Wang,Lihui Zhou,You-Shui Gao,Zubin Zhou,Xiaowei Yu
出处
期刊:ACS Infectious Diseases
[American Chemical Society]
日期:2022-04-12
卷期号:8 (5): 918-927
被引量:8
标识
DOI:10.1021/acsinfecdis.1c00459
摘要
Osteomyelitis is a Staphylococcus aureus-caused bone infection. In this study, the effects of miR-146a on osteomyelitis were evaluated. Using the osteoblast cell model and S. aureus-induced osteomyelitis mice model, we monitored the miR-146 expression and explored the effects of miR-146a on cell proliferation of osteoblasts, bone remodeling, osteoclastogenesis, inflammatory cytokine production, and bacterial burden. Upregulated miR-146a was found in mice with S. aureus-induced osteomyelitis. miR-146a attenuated S. aureus-induced cell loss of osteoblasts, rescued the expression of osteogenic markers, altered the bone remodeling, and inhibited inflammatory cytokine production and osteoclastogenesis. miR-146a knockout mice had higher S. aureus burden. In conclusion, miR-146a protects against S. aureus-induced osteomyelitis by regulating inflammation and osteogenesis.
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