蒙脱石
药物输送
煅烧
控制释放
化学
毒品携带者
胃液
纳米复合材料
封装(网络)
氨基水杨酸
化学工程
傅里叶变换红外光谱
材料科学
核化学
纳米技术
色谱法
有机化学
药理学
计算机科学
催化作用
医学
工程类
计算机网络
作者
Marinela Victoria Dumitru,Teodor Sandu,Ana Lorena Ciurlică,Iulia Elena Neblea,Bogdan Trică,Adi Ghebaur,Sorina Alexandra Gârea,Horia Iovu,Andrei Sârbu,Tanţa-Verona Iordache
标识
DOI:10.1016/j.clay.2022.106415
摘要
This paper is aimed at developing innovative hybrid nanocomposites, further used as controlled release systems suited for the therapy of Inflammatory Bowel Diseases (IBDs). To this purpose, a layered silicate, i.e. montmorillonite (MMT), was investigated in terms of its potential to act as carrier in the drug delivery, whereas 5-aminosalicylic acid (5-ASA) was used as model pharmaceutical drug. Prior to the encapsulation step, MMT was thermally treated and afterwards chemically modified with γ- methacryloxypropyltrimethoxysilane (MAPTES) to endow it with organic moieties. Hence, an organophilization process was performed to strengthen the interactions between MMT and 5-ASA. Finally, the pursued formulations were developed by encapsulating 5-ASA within the MAPTES-modified MMT. In order to prove that both organophilization and encapsulation were carried out successfully, FTIR spectra, XRD patterns and TEM images were recorded. The encapsulation efficiencies and the release profiles of 5-ASA were investigated by means of UV–Vis spectroscopy in simulated gastric fluid (pH = 1.2) and simulated intestinal fluid (pH = 6.8). It was found that calcined MMT followed by silylation yielded the most promising results in terms of 5-ASA encapsulation efficiency, low burst release and constancy of release rates at both pH studied values.
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