医学
对乙酰氨基酚
肝衰竭
肝移植
乙酰半胱氨酸
解热药
止痛药
酚中毒
毒性
重症监护医学
肝毒性
肝损伤
药理学
麻醉
移植
外科
内科学
生物化学
化学
抗氧化剂
标识
DOI:10.1016/j.cld.2007.06.006
摘要
Acetaminophen is a commonly used antipyretic and analgesic agent. It is safe when taken at therapeutic doses; however, overdose can lead to serious and even fatal hepatotoxicity. The initial metabolic and biochemical events leading to toxicity have been well described, but the precise mechanism of cell injury and death is unknown. Prompt recognition of overdose, aggressive management, and administration of N-acetylcysteine can minimize hepatotoxicity and prevent liver failure and death. Liver transplantation can be lifesaving for those who develop acute liver failure.
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