微泡
纳米载体
脂质体
胞外囊泡
靶向给药
生物物理学
药品
化学
小泡
体内
纳米技术
外体
纳米医学
分子成像
细胞穿透肽
材料科学
基因传递
作者
Mujib Ullah,Sai Priyanka Kodam,Qian Sarah Mu,Asma Akbar
出处
期刊:ACS Nano
[American Chemical Society]
日期:2021-03-05
卷期号:15 (3): 3612-3620
被引量:32
标识
DOI:10.1021/acsnano.0c10689
摘要
Extracellular vesicles (EVs) and microbubbles are nanoparticles in drug-delivery systems that are both considered important for clinical translation. Current research has found that both microbubbles and EVs have the potential to be utilized as drug-delivery agents for therapeutic targets in various diseases. In combination with EVs, microbubbles are capable of delivering chemotherapeutic drugs to tumor sites and neighboring sites of damaged tissues. However, there are no standards to evaluate or to compare the benefits of EVs (natural carrier) versus microbubbles (synthetic carrier) as drug carriers. Both drug carriers are being investigated for release patterns and for pharmacokinetics; however, few researchers have focused on their targeted delivery or efficacy. In this Perspective, we compare EVs and microbubbles for a better understanding of their utility in terms of delivering drugs to their site of action and future clinical translation.
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