医学
他克莫司
肝移植
不利影响
科克伦图书馆
加药
优势比
荟萃分析
移植
入射(几何)
内科学
泌尿科
光学
物理
作者
Bingqing Huang,Jun Li,Jun Li,Paul M. Schroder,Maogen Chen,Ronghai Deng,Shijie Deng
标识
DOI:10.1016/j.japh.2019.08.002
摘要
Objective For patients who have received a kidney transplant, studies have shown that once-daily prolonged-release tacrolimus (TAC) has similar efficacy and safety to standard twice-daily dosing. The purpose of this study was to perform a meta-analysis to compare the effectiveness and safety of daily TAC (TAC qd) versus standard twice-daily TAC (TAC bid) administration in liver transplantation (LT). Design Meta-analysis. Setting and participants We systematically searched the PubMed/MEDLINE, Web of Science, and Cochrane Library databases for studies comparing outcomes of LT patients who received TAC qd versus TAC bid. Outcome measures Results were reported as odds ratios (ORs) with 95% CIs. Results Six studies, which included 5179 LT recipients (TAC qd = 951; TAC bid = 4228) were included in the analysis. The TAC qd group had a low 1-year graft loss rate (OR 0.70 [95% CI 0.54–0.91], P = 0.008) and lower rate of biopsy-proven acute rejection (BPAR) at 90 days (OR 0.46 [95% CI 0.24–0.89], P = 0.02) compared with the TAC bid group. There was no significant difference in 1-year mortality or the incidence of adverse events after LT between the 2 groups. Conclusions Current evidence suggests that TAC qd is safe and effective for LT patients during the first year after transplantation. Longer-term follow-up studies are necessary to determine if TAC qd is safe and effective beyond the first year after LT.
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