霍乱弧菌
霍乱毒素
霍乱
毒力
囊性纤维化跨膜传导调节器
作用机理
安普克
毒力因子
调节器
药品
蛋白激酶A
医学
药理学
生物
囊性纤维化
微生物学
激酶
细胞生物学
生物化学
细菌
内科学
基因
体外
遗传学
作者
Francisca Beatriz M. Sousa,Isabela R S G Nolêto,Leticia Santos Chaves,Gabriella Pacheco,Ana Patrícia de Oliveira,Mikhail M V Fonseca,Jand Venes Rolim Medeiros
摘要
Abstract Objectives The oral rehydration solution is the most efficient method to treat cholera; however, it does not interfere in the action mechanism of the main virulence factor produced by Vibrio cholerae, the cholera toxin (CT), and this disease still stands out as a problem for human health worldwide. This review aimed to describe therapeutic alternatives available in the literature, especially those related to the search for molecules acting upon the physiopathology of cholera. Key findings New molecules have offered a protection effect against diarrhoea induced by CT or even by infection from V. cholerae. The receptor regulator cystic fibrosis channel transmembrane (CFTR), monosialoganglioside (GM1), enkephalinase, AMP-activated protein kinase (AMPK), inhibitors of expression of virulence factors and activators of ADP-ribosylarginine hydrolase are the main therapeutic targets studied. Many of these molecules or extracts still present unclear action mechanisms. Conclusions Knowing therapeutic alternatives and their molecular mechanisms for the treatment of cholera could guide us to develop a new drug that could be used in combination with the rehydration solution.
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