胶质瘤
增强子
生物
癌症研究
小RNA
表型
抄写(语言学)
基因
转录因子
癌症
遗传学
语言学
哲学
作者
Meng Cheng,Zheng Wei Zhang,Xing Ji,Yadi Xu,Erbao Bian,Bing Zhao
标识
DOI:10.1016/j.bbcan.2020.188353
摘要
Glioma is the most common primary malignant tumor in the human brain. Although there are a variety of treatments, such as surgery, radiation and chemotherapy, glioma is still an incurable disease. Super-enhancers (SEs) are implicated in the control of tumor cell identity, and they promote oncogenic transcription, which supports tumor cells. Inhibition of the SE complex, which is required for the assembly and maintenance of SEs, may repress oncogenic transcription and impede tumor growth. In this review, we discuss the unique characteristics of SEs compared to typical enhancers, and we summarize the recent advances in the understanding of their properties and biological role in gene regulation. Additionally, we highlight that SE-driven lncRNAs, miRNAs and genes are involved in the malignant phenotype of glioma. Most importantly, the application of SE inhibitors in different cancer subtypes has introduced new directions in glioma treatment.
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