炎症体
小胶质细胞
半胱氨酸蛋白酶1
上睑下垂
程序性细胞死亡
细胞内
半胱氨酸蛋白酶
神经科学
疾病
细胞生物学
免疫学
炎症
生物
医学
细胞凋亡
病理
遗传学
作者
J. Walsh,Daniel A. Muruve,Christopher Power
摘要
Since their discovery in 2002, inflammasomes have been shown to be crucial mediators of caspase 1 activation, interleukin-1β and interleukin-18 release, and pyroptotic cell death. This Review describes our current understanding of the functions of different inflammasomes in the CNS and their roles in neurological diseases. Microglia and macrophages in the CNS contain multimolecular complexes termed inflammasomes. Inflammasomes function as intracellular sensors for infectious agents as well as for host-derived danger signals that are associated with neurological diseases, including meningitis, stroke and Alzheimer's disease. Assembly of an inflammasome activates caspase 1 and, subsequently, the proteolysis and release of the cytokines interleukin-1β and interleukin-18, as well as pyroptotic cell death. Since the discovery of inflammasomes in 2002, there has been burgeoning recognition of their complexities and functions. Here, we review the current understanding of the functions of different inflammasomes in the CNS and their roles in neurological diseases.
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