医学
血管内超声
支架
内膜增生
病变
动脉
心脏病学
靶病变
放射科
经皮冠状动脉介入治疗
内科学
外科
心肌梗塞
平滑肌
作者
Avinoam Shiran,Neil J. Weissman,Borjanca Leiboff,Kenneth M. Kent,Augusto D. Pichard,Lowell F. Satler,Hongsheng Wu,Martin B. Leon,Gary S. Mintz
标识
DOI:10.1016/s0002-9149(00)01234-0
摘要
We sought to determine if axial and circumferential distribution of plaque before stenting determines the axial and circumferential distribution of subsequent intimal hyperplasia (IH). We studied 22 patients with a single Palmaz-Schatz stent implanted in a native coronary artery, who underwent intravascular ultrasound (IVUS) imaging before intervention, after stenting, and at 6-month follow-up. For each lesion, 7 locations were analyzed: proximal and distal reference, proximal and distal edge of the stent, proximal and distal location within the body of the stent, and the articulation. Pre- and postintervention and follow-up image slices were precisely aligned and analyzed for pre- and postintervention plaque area and follow-up IH area and thickness. The location of maximal IH area was at or adjacent to the location of maximal preintervention plaque in 17 of 22 of the patients (77%). Similiarly, the circumferential distribution of IH at follow-up paralleled the eccentricity pattern of the native plaque burden in 69% (24 of 35 slices). Using multivariant analysis, the strongest predictor of IH was preintervention plaque area (p = 0.001). IH accumulates axially and circumferentially preferentially at the site of maximal preintervention plaque.
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