衰老
表型
炎症
机制(生物学)
疾病
风险因素
细胞衰老
免疫学
医学
生物
生物信息学
老化
老年学
遗传学
内科学
基因
哲学
认识论
作者
Tamar Tchkonia,Yi Zhu,Jan van Deursen,Judith Campisi,James L. Kirkland
摘要
Aging is the largest risk factor for most chronic diseases, which account for the majority of morbidity and health care expenditures in developed nations. New findings suggest that aging is a modifiable risk factor, and it may be feasible to delay age-related diseases as a group by modulating fundamental aging mechanisms. One such mechanism is cellular senescence, which can cause chronic inflammation through the senescence-associated secretory phenotype (SASP). We review the mechanisms that induce senescence and the SASP, their associations with chronic disease and frailty, therapeutic opportunities based on targeting senescent cells and the SASP, and potential paths to developing clinical interventions.
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