脂质代谢
发病机制
脂滴
非酒精性脂肪肝
疾病
生物
计算生物学
细胞生物学
化学
生物化学
医学
脂肪肝
免疫学
病理
作者
Brian T. Kalish,Gillian L. Fell,Prathima Nandivada,Mark Puder
标识
DOI:10.1177/0148607115595974
摘要
Lipids not only are fundamental nutrients but also serve as basic structural components of cells and as multifunctional signaling molecules. Lipid metabolism pathways underlie basic processes in health and disease and are the targets of novel therapeutics. In this review, we explore the molecular control of lipid synthesis, trafficking, and storage, with a focus on clinically relevant pathways. To illustrate the clinical relevance of molecular lipid regulation, we highlight how these biochemical processes contribute to the pathogenesis of nonalcoholic fatty liver disease, a component of the metabolic syndrome and a paradigmatic example of lipid dysregulation.
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