粒细胞
粒细胞巨噬细胞集落刺激因子
粒细胞集落刺激因子
吞噬作用
造血生长因子
免疫学
造血
集落刺激因子
免疫系统
粒-巨噬细胞集落刺激因子受体
生物
呼吸爆发
脱颗粒
生长因子
巨噬细胞
细胞因子
体外
巨噬细胞集落刺激因子
细胞生物学
干细胞
受体
生物化学
化疗
遗传学
出处
期刊:Current Opinion in Hematology
[Ovid Technologies (Wolters Kluwer)]
日期:1997-01-01
卷期号:4 (3): 183-190
被引量:49
标识
DOI:10.1097/00062752-199704030-00005
摘要
The hematopoietic growth factors granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) not only regulate the numbers of circulating neutrophils but also modulate the function of mature cells. Additionally, newly developed neutrophils subsequently released from the bone marrow in response to colony-stimulating factors (CSFs) also have enhanced function. A variety of different functions are affected, including changes in adherence, movement, phagocytosis, priming and stimulation of the respiratory burst, secretion, and degranulation. These effects also can cause increased microbicidal capacity in vitro, ex vivo, and in vivo. Both G-CSF and GM-CSF have such effects on neutrophil function, but there are differences that may result in precise modulation of the immune responses and may have implications for choice of agents for immune-based therapy for different conditions.
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