囊性纤维化
铜绿假单胞菌
脂多糖
脂质A
气道
微生物学
假单胞菌
假单胞菌科
免疫学
医学
化学
生物
细菌
内科学
麻醉
遗传学
作者
Robert K. Ernst,Eugene C. Yi,Lin Guo,Kheng B. Lim,Jane L. Burns,Murray Hackett,Samuel I. Miller
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1999-11-19
卷期号:286 (5444): 1561-1565
被引量:487
标识
DOI:10.1126/science.286.5444.1561
摘要
Cystic fibrosis (CF) patients develop chronic airway infections with Pseudomonas aeruginosa (PA). Pseudomonas aeruginosa synthesized lipopolysaccharide (LPS) with a variety of penta- and hexa-acylated lipid A structures under different environmental conditions. CF patient PA synthesized LPS with specific lipid A structures indicating unique recognition of the CF airway environment. CF-specific lipid A forms containing palmitate and aminoarabinose were associated with resistance to cationic antimicrobial peptides and increased inflammatory responses, indicating that they are likely to be involved in airway disease.
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