PRC2
热空气
生物
脱甲基酶
组蛋白
抑制因子
抄写(语言学)
遗传学
非编码RNA
核糖核酸
基因
长非编码RNA
细胞生物学
组蛋白H3
转录因子
哲学
语言学
作者
Ming Ying Tsai,Ohad Manor,Yao Wan,Nima Mosammaparast,Jordon K. Wang,Fei Lan,Yang Shi,Eran Segal,Howard Y. Chang
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2010-08-06
卷期号:329 (5992): 689-693
被引量:2882
标识
DOI:10.1126/science.1192002
摘要
A Lot of HOTAIR The roles of several classes of small (<50 nucleotides) noncoding RNAs are beginning to be defined in molecular detail, whereas the function of most of the long (∼200+ nucleotides), intergenic noncoding (linc)RNAs found in most eukaryotic genomes remains something of a mystery. The HOTAIR lincRNA, which is transcribed from the mouse HOXC locus, binds to the Polycomb Repressive Complex 2 (PRC2) and recruits it to HOXD and other genes, where its histone methylase activity acts to repress gene transcription. Tsai et al. (p. 689 , published online 8 July) now show that HOTAIR also binds to a histone demethylase enzyme, LSD1, part of the CoREST/REST repressor complex. LSD1 acts to remove transcription-activating histone marks, reinforcing the repressive activity of the PRC2 complex. HOTAIR thus functions as a platform for the coordinated binding of PRC2 and LSD1-containing complexes to genes, as revealed in a genome-wide analysis of PRC1/CoREST/REST co-regulated genes.
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