生物
CpG站点
基因
遗传学
甲基化
DNA甲基化
癌变
基因组印记
印记(心理学)
基因组
基因表达
作者
Sally H. Cross,Adrian Bird
标识
DOI:10.1016/0959-437x(95)80044-1
摘要
Of the estimated 45,000 CpG islands in the human genome, the overwhelming majority are found at the 5' ends of genes and their identification and cloning are proving very useful for finding and isolating genes. Recent work has shed light on the chromosomal distribution and origin of CpG islands. It has been shown unequivocally that CpG islands are concentrated in the R band chromosomal regions and that intact transcription factor binding sites and required for their maintenance. Cases of methylation of CpG islands and inactivation of the associated genes have been reported which may be important in ageing, tumorigenesis and imprinting.
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