止血
止血剂
肾切除术
失血
医学
肾
化学
外科
麻醉
内科学
作者
Hong Sui,Lanlan Zhang,Chao Wang
标识
DOI:10.1002/mabi.200900129
摘要
Abstract We evaluated the hemostatic efficacy of a biological self‐assembling peptide RADA16‐I in a rat kidney injury model. Adult male rats were randomized into five groups: sham operation (no renal excision), no hemostatic agent (control), commercially available gelatin sponge (Gelfoam), 1% RADA16‐I, and 2% RADA16‐I. After left partial nephrectomy, the anesthetized animal was anticoagulated using 300 IU · kg −1 heparin, and the topical hemostatic agent was applied to the injury. Blood loss and mean arterial pressure (MAP) were recorded. As was the case for Gelfoam, 2% RADA16‐I produced marked hemostasis versus controls ( p < 0.01). Blood loss with 1% and 2% RADA16‐I was significantly less than controls. The decline in MAP during surgery was less with 2% versus 1% RADA16‐I. RADA16‐I also resulted in less histological tissue responses than Gelfoam. These data suggest that RADA16‐I can stop hemorrhage, with only minimal tissue responses, in experimental renal injury. magnified image
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