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Oncogenes and anti‐oncogenes; the molecular basis of tumour behaviour

引用 图书馆学 医学 计算机科学
作者
David Wynford‐Thomas
出处
期刊:The Journal of Pathology [Wiley]
卷期号:165 (3): 187-201 被引量:69
标识
DOI:10.1002/path.1711650302
摘要

The Journal of PathologyVolume 165, Issue 3 p. 187-201 Review Article Oncogenes and anti-oncogenes; the molecular basis of tumour behaviour D. Wynford-Thomas, Corresponding Author D. Wynford-Thomas CRC Thyroid Tumour Biology Research Group, Department of Pathology, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, U.K.CRC Thyroid Tumour Biology Research Group, Department of Pathology, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, U.K.Search for more papers by this author D. Wynford-Thomas, Corresponding Author D. Wynford-Thomas CRC Thyroid Tumour Biology Research Group, Department of Pathology, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, U.K.CRC Thyroid Tumour Biology Research Group, Department of Pathology, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, U.K.Search for more papers by this author First published: November 1991 https://doi.org/10.1002/path.1711650302Citations: 62AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Stehelin D, Guntaka RV, Varmus HE, Bishop JM Purification of DNA complementary to nucleotide sequences required for neoplastic transformation of fibroblasts by avian sarcoma viruses. J Mol Biol 1976; 101: 349–365. 10.1016/0022-2836(76)90152-2 CASPubMedWeb of Science®Google Scholar 2 Parada LF, Tabin CJ, Shih C, Weinberg RA Human EJ bladder carcinoma oncogene is a homologue of Harvey sarcoma virus ras gene. Nature 1982; 297: 474–478. 10.1038/297474a0 CASPubMedWeb of Science®Google Scholar 3 Waterfield MD, Scrace GT, Whittle N, et al. Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus. Nature 1983; 304: 35–39. 10.1038/304035a0 CASPubMedWeb of Science®Google Scholar 4 Sporn MB, Todaro GJ Autocrine secretion and malignant transformation of cells. N Engl J Med 1980; 303: 878–880. 10.1056/NEJM198010093031511 CASPubMedWeb of Science®Google Scholar 5 Cuttitta F, Carney DN, Mulshine J, et al. Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer. Nature 1985; 316: 823–826. 10.1038/316823a0 CASPubMedWeb of Science®Google Scholar 6 Coffey RJ Jr, Derynck R, Wilcox JN, et al. Production and autoinduction of transforming growth factor-α in human keratinocytes. Nature 1987; 328: 817–820. 10.1038/328817a0 CASPubMedWeb of Science®Google Scholar 7 Ullrich A, Coussens L, Hayflick JS, et al. Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells. Nature 1984; 309: 418–425. 10.1038/309418a0 CASPubMedWeb of Science®Google Scholar 8 Berger MS, Gullick WJ, Greenfield C, Evans S, Addis BJ, Waterfield MD Epidermal growth factor receptors in lung tumours. J Pathol 1987; 152: 297–307. 10.1002/path.1711520408 CASPubMedWeb of Science®Google Scholar 9 Gullick WJ, Marsden JJ, Whittle N, Ward B, Bobrow L, Waterfield MD Expression of epidermal growth factor receptors on human cervical, ovarian and vulval carcinomas. Cancer Res 1986; 46: 285–292. CASPubMedWeb of Science®Google Scholar 10 Libermann TA, Nusbaum HR, Razon N, et al. Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin. Nature 1985; 313: 144–147. 10.1038/313144a0 CASPubMedWeb of Science®Google Scholar 11 Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987; 235: 177–182. 10.1126/science.3798106 CASPubMedWeb of Science®Google Scholar 12 Yokota J, Toyoshima K, Sugimura T, et al. Amplification of c-erbB-2 oncogene in human adenocarcinomas in vivo. Lancet 1986; 1: 765–766. 10.1016/S0140-6736(86)91782-4 CASPubMedWeb of Science®Google Scholar 13 Falck VG, Gullick WJ, C-erbB-2 oncogene product staining in gastric adenocarcinoma. An immunohistochemical study. J Pathol 1989; 159: 107–111. 10.1002/path.1711590204 CASPubMedWeb of Science®Google Scholar 14 Lemoine NR, Staddon S, Dickson C, Barnes DM, Gullick WJ Absence of activating transmembrane mutations in the c-erbB-2 proto-oncogene in human breast cancer. Oncogene 1990; 5: 237–242. CASPubMedWeb of Science®Google Scholar 15 Kraus MH, Issing W, Miki T, Popescu NC, Aaronson SA Isolation and characterization of erbB3, a third member of the erbB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. Proc Natl Acad Sci USA 1989; 86: 9193–9197. 10.1073/pnas.86.23.9193 CASPubMedWeb of Science®Google Scholar 16 Humphrey PA, Wong AJ, Vogelstein B, et al. Anti-synthetic peptide antibody reacting at the fusion junction of deletion mutant epidermal growth factor receptors in human glioblastoma. Proc Natl Acad Sci USA 1990; 87: 4207–4211. 10.1073/pnas.87.11.4207 CASPubMedWeb of Science®Google Scholar 17 Ridge SA, Worwood M, Oscier D, Jacobs A, Padua RA FMS mutations in myelodysplastic, leukemic, and normal subjects. Proc Natl Acad Sci USA 1990; 87: 1377–1380. 10.1073/pnas.87.4.1377 CASPubMedWeb of Science®Google Scholar 18 Bos JL, Fearon ER, Hamilton SR, et al. Prevalence of ras gene mutations in human colorectal cancers. Nature 1987; 327: 293–297. 10.1038/327293a0 CASPubMedWeb of Science®Google Scholar 19 Almoguera C, Shibata D, Forrester K, Martin J, Arnheim N, Perucho M. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 1988; 53: 549–554. 10.1016/0092-8674(88)90571-5 CASPubMedWeb of Science®Google Scholar 20 Padua RA, Carter G, Hughes D. et al. Ras mutations in myelodysplasia detected by amplification, oligonucleotide hybridization and transformation. Leukemia 1988; 2: 503–510. CASPubMedWeb of Science®Google Scholar 21 Lemoine NR, Mayall ES, Wyllie FS, et al. High frequency of ras oncogene activation in all stages of human thyroid tumorigenesis. Oncogene 1989; 4: 159–164. CASPubMedWeb of Science®Google Scholar 22 Hancock JF, Magee AI, Childs JE, Marshall CJ All ras proteins are polyisoprenylated but only some are palmitoylated. Cell 1989; 57: 1167–1177. 10.1016/0092-8674(89)90054-8 CASPubMedWeb of Science®Google Scholar 23 Mulcahy LS, Smith MR, Stacey DW Requirement for ras protooncogene function during serum-stimulated growth of NIH 3T3 cells. Nature 1985; 313: 241–243. 10.1038/313241a0 CASPubMedWeb of Science®Google Scholar 24 Downward J, Graves JD, Warne PH, Rayter S, Cantrell DA Stimulation of p21ras upon T-cell activation. Nature 1990; 346: 719–723. 10.1038/346719a0 CASPubMedWeb of Science®Google Scholar 25 Downward J, Riehl R, Wu L, Weinberg RA Identification of a nucleotide exchange-promoting activity for p21ras. Proc Natl Acad Sci USA 1990; 87: 5998–6002. 10.1073/pnas.87.15.5998 CASPubMedWeb of Science®Google Scholar 26 McCormick F. The world according to GAP. Oncogene 1990; 5: 1281–1283. CASPubMedWeb of Science®Google Scholar 27 Molloy CJ, Bottaro DP, Fleming TP, Marshall MS, Gibbs JB, Aaronson SA PDGF induction of tyrosine phosphorylation of GTPase activating protein. Nature 1989; 342: 711–714. 10.1038/342711a0 CASPubMedWeb of Science®Google Scholar 28 Housey GM, Johnson MD, Hsiao WLW, et al. Overproduction of protein kinase C causes disordered growth control in rat fibroblasts. Cell 1988; 52: 343–354. 10.1016/S0092-8674(88)80027-8 CASPubMedWeb of Science®Google Scholar 29 Landis CA, Masters SB, Spada A, Pace AM, Bourne HR, Vallar L. GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours. Nature 1989; 340: 692–696. 10.1038/340692a0 CASPubMedWeb of Science®Google Scholar 30 Lyons J, Landis CA, Harsh G, et al. Two G protein oncogenes in human endocrine tumours. Science 1990; 249: 655–659. 10.1126/science.2116665 CASPubMedWeb of Science®Google Scholar 31 Cantley LC, Auger KR, Carpenter C, et al. Oncogenes and signal transduction. Cell 1991; 64: 281–302. 10.1016/0092-8674(91)90639-G CASPubMedWeb of Science®Google Scholar 32 Hunter T. Oncogene products in the cytoplasm: the protein kinases. In: RA Weinberg, ed. Oncogenes and the Molecular origins of Cancer, Cold Spring Harbor: Cold Spring Harbor Press 1989; 159. Web of Science®Google Scholar 33 Arlinghaus RB. Involvement of the abl proto-oncogene in human leukemias. In: D Carney, S Sikora, eds. Genes and Cancer, New York: Wiley, 1990; 65–71. Google Scholar 34 Shivelman E, Lifshitz B, Gale RP, Canaani E. Fused transcript of abl and ber genes in chronic myelogenous leukaemia. Nature 1985; 315: 550–554. 10.1038/315550a0 PubMedWeb of Science®Google Scholar 35 Mitchell RL, Zokas L, Schreiber RD, Verma IM Rapid induction of the expression of proto-oncogene fos during human monocytic differentiation. Cell 1985; 40: 209–217. 10.1016/0092-8674(85)90324-1 CASPubMedWeb of Science®Google Scholar 36 Jenuwein T, Muller D, Curran T, Muller R. Extended life span and tumorigenicity of nonestablished mouse connective tissue cells transformed by the fos oncogene of FBR-MuSV. Cell 1985; 41: 629–637. 10.1016/S0092-8674(85)80035-0 CASPubMedWeb of Science®Google Scholar 37 U HS, Kelley P, Lee W-H. Abnormalities of the human growth hormone gene and proto-oncogenes in some human pituitary adenomas. Mol Endocrinol 1988; 2: 85–89. 10.1210/mend-2-1-85 CASPubMedGoogle Scholar 38 Stewart TA, Bellve AR, Leder P. Transcription and promoter usage of the myc gene in normal somatic and spermatogenic cells. Science 1984; 226: 707–710. 10.1126/science.6494906 CASPubMedWeb of Science®Google Scholar 39 Varley JM, Swallow JE, Brammar WJ, Whittaker JL, Walker RA Alterations to either c-erbB-2 (neu) or c-myc proto-oncogenes in breast carcinomas correlate with poor short-term prognosis. Oncogene 1987; 1: 432–430. Google Scholar 40 Little CD, Nau MM, Carney DN, Gazdar AF, Minna JD Amplification and expression of the c-myc oncogene in human lung cancer cell lines. Nature 1983; 306: 194–196. 10.1038/306194a0 CASPubMedWeb of Science®Google Scholar 41 Rabbitts TH, Rabbitts PH. Molecular pathology of chromosomal abnormalities and cancer genes in human tumours. In: DM Glover, BD Hames, eds. Oncogenes. Oxford: IRL Press, 1989; 67–111. Google Scholar 42 Erisman MD, Scott JK, Astrin SM Evidence that the familial adenomatous polyposis gene is involved in a subset of colon cancers with a complementable defect in c-myc regulation. Proc Natl Acad Sci USA 1989; 86: 4264–4268. 10.1073/pnas.86.11.4264 CASPubMedWeb of Science®Google Scholar 43 Solomon E, Voss R, Hall V, et al. Chromosome 5 allele loss in human colorectal carcinomas. Nature 1987; 328: 616–619. 10.1038/328616a0 CASPubMedWeb of Science®Google Scholar 44 Zimmerman KA, Yancopoulos GD, Collum RG, et al. Differential expression of myc family genes during murine development. Nature 1986; 319: 780–783. 10.1038/319780a0 CASPubMedWeb of Science®Google Scholar 45 Seeger RC, Brodeur GM, Sather H, et al. Association of multiple copies of the n-myc oncogene with rapid progression of neuroblastomas. N Engl J Med 1985; 313: 1111–1116. 10.1056/NEJM198510313131802 CASPubMedWeb of Science®Google Scholar 46 Lane DP, Crawford LV Tantigen is bound to a host protein in SV40-transformed cells. Nature 1979; 278: 261–263. 10.1038/278261a0 CASPubMedWeb of Science®Google Scholar 47 Reich NC, Levine AJ Growth regulation of a cellular tumour antigen. p53, in nontransformed cells. Nature 1984; 308: 199–201. 10.1038/308199a0 CASPubMedWeb of Science®Google Scholar 48 Mercer WE, Avignolo C, Baserga R. Role of the p53 protein in cell proliferation as studied by microinjection of monoclonal antibodies. Mol Cell Biol 1984; 4: 276–281. 10.1128/MCB.4.2.276 CASPubMedWeb of Science®Google Scholar 49 Williams NW, Wynford-Thomas D. Oncoprotein p53 expression in normal, immortalized and transformed mouse fibroblasts. Exp Cell Res 1989; 184: 316–328. 10.1016/0014-4827(89)90331-5 CASPubMedWeb of Science®Google Scholar 50 Bos JL Ras oncogenes in human cancer: a review. Cancer Res 1989; 49: 4682–4689. CASPubMedWeb of Science®Google Scholar 51 Lemoine NR, Staddon S, Bond J, Wyllie FS, Shaw JJ, Wynford-Thomas D. Partial transformation of human thyroid epithelial cells bu mutant Ha-ras oncogene. Oncogene 1990; 5: 1833–1837. CASPubMedWeb of Science®Google Scholar 52 Redmond SMS, Reichmann E, Muller RG, Friis RR, Groner B, Hynes NE The transformation of primary and established mouse mammary epithelial cells by p21-ras is concentration dependent. Oncogene 1988; 2: 259–265. CASPubMedWeb of Science®Google Scholar 53 Wright N, Alison M. The Biology of Epithelial Cell Populations. Oxford: Clarendon Press, 1984; 21–96. Google Scholar 54 Wynford-Thomas D, Stringer BMJ, Williams ED Dissociation of growth and function in the rat thyroid during prolonged goitrogen administration. Acta Endocrinol 1982; 101: 210–216. CASPubMedWeb of Science®Google Scholar 55 Lemoine NR, Mayall ES, Williams ED, Thurston V, Wynford-Thomas D. Agent specific ras oncogene activation in rat thyroid tumours. Oncogene 1988; 3: 541–544. CASPubMedWeb of Science®Google Scholar 56 Murphree AL, Benedict WF Retinoblastoma: clues to human oncogenesis. Science 1984; 223: 1028–1033. 10.1126/science.6320372 CASPubMedWeb of Science®Google Scholar 57 Mihara K, Cao X-R, Yen A, et al. Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product. Science 1989; 246: 1300–1303. 10.1126/science.2588006 CASPubMedWeb of Science®Google Scholar 58 Varley JM, Armour J, Swallows JE, et al. The retinoblastoma gene is frequently altered leading to loss of expression in primary breast tumours. Oncogene 1989; 4: 725–729. CASPubMedWeb of Science®Google Scholar 59 Harbour JW, Lai S-L, Whang-Peng J, Gazdar AF, Minna JD, Kaye FJ Abnormalities in structure and expression of the human retinoblastoma gene in SCLS. Science 1988; 241: 353–357. 10.1126/science.2838909 CASPubMedWeb of Science®Google Scholar 60 Horowitz JM, Park S-H, Bogenmann E, et al. Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells. Proc Natl Acad Sci USA 1990; 87: 2775–2779. 10.1073/pnas.87.7.2775 CASPubMedWeb of Science®Google Scholar 61 Malkin D, Li FP, Strong LC, et al. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 1990; 250: 1233–1238. 10.1126/science.1978757 CASPubMedWeb of Science®Google Scholar 62 Fearon ER, Cho KR, Nigro JM, et al. Identification of a chromosome 18q gene that is altered in colorectal cancers. Science 1990; 247: 49–56. 10.1126/science.2294591 CASPubMedWeb of Science®Google Scholar 63 Baker SJ, Fearon ER, Nigro JM, et al. Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science 1989; 244: 217–221. 10.1126/science.2649981 CASPubMedWeb of Science®Google Scholar 64 Prosser J, Thompson AM, Cranston G, Evans HJ Evidence that p53 behaves as a tumour suppressor gene in sporadic breast tumours. Oncogene 1990; 5: 1573–1579. CASPubMedWeb of Science®Google Scholar 65 Iggo R, Gatter K, Bartek J, Lane D, Harris AL Increased expression of mutant forms of p53 oncogene in primary lung cancer. Lancet 1990; 335: 675–679. 10.1016/0140-6736(90)90801-B CASPubMedWeb of Science®Google Scholar 66 Gannon JV, Greaves R, Iggo R, Lane DP Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form. EMBO J 1990; 9: 1595–1602. 10.1002/j.1460-2075.1990.tb08279.x CASPubMedWeb of Science®Google Scholar 67 Nigro JM, Baker SJ, Preisinger AC, et al. Mutations in the p53 gene occur in diverse human tumour types. Nature 1989; 342: 705–708. 10.1038/342705a0 CASPubMedWeb of Science®Google Scholar 68 Vogelstein B, Fearon ER, Hamilton SR, et al. Genetic alterations during colorectal-tumour development. N Engl J Med 1988; 319: 525–532. 10.1056/NEJM198809013190901 CASPubMedWeb of Science®Google Scholar 69 Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990; 61: 759–767. 10.1016/0092-8674(90)90186-I CASPubMedWeb of Science®Google Scholar 70 Kinzler KW, Nilbert MC, Vogelstein B, et al. Identification of a gene located at chromosome 5q21 that is mutated in colorectal carcinomas. Science 1991; 251: 1366–1370. 10.1126/science.1848370 CASPubMedWeb of Science®Google Scholar 71 Land H, Parada LF, Weinberg RA Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature 1983; 304: 596–602. 10.1038/304596a0 CASPubMedWeb of Science®Google Scholar 72 Shukla VK, Hughes DC, Hughes LE, McCormick F, Padua RA Ras mutations in human melanotic lesions: K-ras activation is a frequent and early event in melanoma development. Oncogene Res 1989; 5: 121–127. CASPubMedWeb of Science®Google Scholar 73 Gill GN, Lazar CS Increased phosphotyrosine content and inhibition of proliferation in EGF-treated A431 cells. Nature 1981; 293: 305–307. 10.1038/293305a0 CASPubMedWeb of Science®Google Scholar 74 Pientenpol JA, Stein RW, Moran E, et al. TGF-β inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains. Cell 1990; 61: 777–785. 10.1016/0092-8674(90)90188-K PubMedWeb of Science®Google Scholar 75 Wyllie FS, Dawson T, Bond JA, et al. Correlated abnormalities of TGFβ1 response and p53 expression in thyroid epithelial cell transformation. Mol Cell Endocrinol 1991; 76: 13–21. 10.1016/0303-7207(91)90255-Q CASPubMedWeb of Science®Google Scholar 76 Hart IR, Goode NT, Wilson RE Molecular aspects of the metastatic cascade. Biochim Biophys Acta 1989; 989: 65–84. CASPubMedWeb of Science®Google Scholar 77 Blood CH, Zetter BR Tumor interactions with the vasculature: Angiogenesis and tumour metastasis. Biochim Biophys Acta 1990; 1032: 89–118. 10.1016/0304-419X(90)90014-R CASPubMedWeb of Science®Google Scholar 78 Basset P, Bellocq JP, Wolf C, et al. A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas. Nature 1990; 348: 699–704. 10.1038/348699a0 CASPubMedWeb of Science®Google Scholar 79 Liotta LA Tumor invasion and metastases-role of the extracellular matrix: Rhoads Memorial Award Lecture. Cancer Res 1986; 46: 1–7. CASPubMedWeb of Science®Google Scholar 80 Eccles SA. The role of oncogenes in metastasis. In: D Carney, K Sikora, eds. Genes and Cancer. New York: Wiley, 1990; 85–96. Google Scholar 81 Greig RG, Koestler TP, Trainer DL, et al. Tumorigenic and metastatic properties of ‘normal’ and ras-transfected NIH/3T3 cells. Proc Natl Acad Sci USA 1985; 82: 3698–3701. 10.1073/pnas.82.11.3698 CASPubMedWeb of Science®Google Scholar 82 Garbisa S, Pozzatti R, Muschel RJ, et al. Secretion of type IV collagenolytic protease and metastatic phenotype: induction by transfection with c-Ha-ras plus Ad2-Ela. Cancer Res 1987; 47: 1523–1528. CASPubMedWeb of Science®Google Scholar 83 Denhardt DT, Greenberg AH, Egan SE, Hamilton RT, Wright JA Cysteine proteinase cathepsin L expression correlates closely with the metastatic potential of H-ras-transformed murine fibroblasts. Oncogene 1987; 2: 55–59. CASPubMedWeb of Science®Google Scholar 84 Denhardt DT, Edwards DR, Parfett CLJ Gene expression during the mammalian cell cycle. Biochim Biophys Acta 1986; 865: 83–125. 10.1016/0304-419X(86)90024-7 CASPubMedWeb of Science®Google Scholar 85 Elder JT, Fisher GJ, Lindquist PB, Overexpression of transforming growth factor α in psoriatic epidermis. Science 1989; 243: 811–814. 10.1126/science.2916128 CASPubMedWeb of Science®Google Scholar 86 Barton CN, Hall PA, Hughes CM, Gullick WJ, Lemoine NR. TGFα and EGF in human pancreatic cancer. J Pathol (in press). Google Scholar 87 Derynck R, Goeddel DV, Ullrich A, et al. Synthesis of messenger RNAs for transforming growth factors α and β and the epidermal growth factor receptor by human tumors. Cancer Res 1987; 47: 707–712. CASPubMedWeb of Science®Google Scholar 88 Yokota J, Yamamoto T, Miyajima N, et al. Genetic alterations of the c-erbB-2 oncogene occur frequently in tubular adenocarcinoma of the stomach and are often accompanied by amplification of the v-erbA homologue. Oncogene 1988; 2: 283–287. CASPubMedWeb of Science®Google Scholar 89 Riou G, Barrios M, Sheng Z-M, Duvillard P, L'homme C. Somatic deletions and mutations of c-Ha-ras gene in human cervical cancers. Oncogene 1988; 3: 329–333. CASPubMedWeb of Science®Google Scholar 90 Furth ME, Aldrich TH, Cordon-Cardo C. Expression of ras proto-oncogene proteins in normal human tissues. Oncogene 1987; 1: 47–58. CASPubMedWeb of Science®Google Scholar 91 Brown K, Quintanilla M, Ramsden M, Kerr IB, Young S, Balmain A. V-ras genes from Harvey and BALB murine sarcoma viruses can act as initiators of two-stage mouse skin carcinogenesis. Cell 1986; 46: 447–456. 10.1016/0092-8674(86)90665-3 CASPubMedWeb of Science®Google Scholar 92 Dotto GP, El-Fouly MH, Nelson C, Trosko JE Similar and synergistic inhibition of gap-junctional communications by ras transformation and tumour promoter treatment of mouse primary keratinocytes. Oncogene 1989; 4: 637–641. CASPubMedWeb of Science®Google Scholar 93 Balmain A, Brown K. Oncogene activation in chemical carcinogenesis. Adv Cancer Res 1988; 51: 147–182. 10.1016/S0065-230X(08)60222-5 CASPubMedWeb of Science®Google Scholar 94 Yuspa SH, Kilkenny AE, Stanley J, Lichti U. Keratinocytes blocked in phorbol ester-responsive early stage of terminal differentiation by sarcoma viruses. Nature 1985; 314: 459–462. 10.1038/314459a0 CASPubMedWeb of Science®Google Scholar 95 Rodenhuis S, Slebos RJC, Boot AJM, et al. Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung. Cancer Res 1988; 48: 5738–5741. CASPubMedWeb of Science®Google Scholar 96 Enomoto T, Inoue M, Perantoni AO, Terakawa N, Tanizawa O, Rice JM, K-ras activation in neoplasms of the human female reproductive tract. Cancer Res 1990; 50: 6139–6145. CASPubMedWeb of Science®Google Scholar 97 Bos JL The ras gene family and human carcinogenesis. Mutat Res 1988; 195: 255–271. 10.1016/0165-1110(88)90004-8 CASPubMedWeb of Science®Google Scholar 98 Hollenstein MC, Smits AM, Galiana C, et al. Amplification of epidermal growth factor receptor gene but no evidence of ras mutations in primary human esophageal cancers. Cancer Res 1988; 48: 5119–5123. PubMedWeb of Science®Google Scholar 99 Rumsby G, Carter RL, Gusterson BA Low incidence of ras oncogene activation in human squamous cell carcinomas. Br J Cancer 1990; 61: 365–368. 10.1038/bjc.1990.80 CASPubMedWeb of Science®Google Scholar 100 Sakamoto H, Mori M, Taira M, et al. Transforming gene from human stomach cancers and a noncancerous portion of stomach mucosa. Proc Natl Acad Sci USA 1986; 83: 3997–4001. 10.1073/pnas.83.11.3997 CASPubMedWeb of Science®Google Scholar Citing Literature Volume165, Issue3November 1991Pages 187-201 ReferencesRelatedInformation

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