[Effect of osmolality on the gastrointestinal permeation of various carbohydrates in healthy persons].

The effect of a high osmotic solution on active and passive sugar permeation was investigated in 19 healthy volunteers. The reduced rate of active sugar absorption (3-O-MG and xylose) out of a high osmotic solution was interpreted as a consequence of an impaired emptying of the stomach. The increased passive permeation of intact disaccharides applied in hyperosmolar solution demonstrates an increased gastrointestinal permeability. Intubation studies suppose increased disaccharide absorption out of hyperosmolar solution in the stomach, i.e. high osmolar solutions increase gastric mucosal permeability.