[Study of SOD and PON-1 expression in type 2 diabetes mellitus nephropathy and its clinical significance].

AIM: To investigate the clinical value of superoxide dismutase(SOD) and paraoxonase-1(PON-1) in type 2 diabetes mellitus(T2DM) nephropathy.METHODS: 80 cases of T2DM patients were divided into T2DM nephropathy group(ND group,40cases) and non-T2DM nephropathy group(non-ND group,40cases),the SOD,PON-1 levels and biochemical levels of the two group were measured,the HOMA-IR was recorded.RESULTS: The SOD and PON-1 levels of the ND group were lower than the non-ND group,compared the difference was significant(P0.05);The FINS,FINS levels and HOMA-IR of the ND group were higher than the non-ND group,compared the difference was significant(P0.05);The FBG,PBG2h and HbAlc levels were no significantly difference(P0.05).Serum SOD,PON-1 levels and HOMA-IR were significantly negatively correlated(r=-0.287,-0.509;P=0.006,0.000),serum SOD level and PON-1 level was no significantly correlated(P0.05).CONCLUSION: The serum SOD and PON-1 involve in the development of T2DM nephropathy.Combined detection of serum SOD and PON-1 have important clinical significance for early diagnosis,prevention,treatment and prognosis of T2DM nephropathy.