Objective:To explore the diabetes and periodontitis treatment and disease progression in the process of interaction,through the clinical detection of diabetes patients with periodontitis before and after treatment of periodontal pocket probing depth,periodontal attachment loss,periodontal attachment loss,glycated hemoglobin,triglycerides,total cholesterol.Methods:20 diabetic patients with periodontitis were time-based comprehensive treatment,and observate the periodontal probing depth,periodontal attachment loss,periodontal attachment loss,glycated hemoglobin,triglycerides and total cholesterol change before and after the treatment.Results:After treatment,PD,SB and AL indexes had a significant decrease,the difference was significant(P0.05).GSP,TG and TC indices also had a significant decrease,the difference was significant(P 0.05).Conclusion:There is the two-way relationship between periodontitis and diabetes periodontal comprehensive treatment can relieve the local periodontal disease status of periodontitis patients,while making improvements in metabolic,and easing the symptoms of diabetes.