头孢哌酮
医学
药代动力学
痰
慢性支气管炎
头孢菌素
支气管炎
抗菌剂
抗生素
胃肠病学
内科学
药理学
微生物学
病理
肺结核
抗生素耐药性
生物
亚胺培南
作者
P.C. Braga,F. Scaglione,S. Villa,G Scarpazza,Gagliardi,Gerardo Biella,Manganelli,G. Paiola,Franco Fraschini
出处
期刊:PubMed
日期:1983-01-01
卷期号:3 (5): 349-55
摘要
Cefoperazone is a third-generation semisynthetic injectable cephalosporin. It has been reported that cefoperazone has beta-lactamase resistance and quite a broad antimicrobial spectrum against many Gram-positive and Gram-negative microorganisms and most anaerobes. In this study, the pharmacokinetics of cefoperazone were examined in a group of 10 patients suffering from acute exacerbations of chronic bronchitis, with purulent or mucopurulent expectorations. Cefoperazone was administered at the dose of 1 g i.m. every 12 hours. Serum and urinary parameters and the profile of bronchial mucus diffusion were assessed after the first administration and during the whole period of treatment which lasted for 7 days. In a second, third, and fourth group of volunteer patients who had to undergo surgical operations, bone, lung and prostatic penetration of cefoperazone was determined in correlation with serum levels.
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