PLGA公司
鼻窦提升术
生物医学工程
乙醇酸
骨膜
脚手架
体内
组织工程
骨愈合
伤口愈合
软组织
体外
牙科
材料科学
化学
医学
乳酸
上颌窦
外科
生物化学
生物技术
生物
细菌
遗传学
作者
Gabriele Ceccarelli,Rossella Presta,Nefele Giarratana,Nora Bloise,Laura Benedetti,Maria Gabriella Cusella De Angelis,Ruggero Rodriguez y Baena
出处
期刊:Molecules
[MDPI AG]
日期:2017-12-02
卷期号:22 (12): 2109-2109
被引量:15
标识
DOI:10.3390/molecules22122109
摘要
Most recent advances in tissue engineering in the fields of oral surgery and dentistry have aimed to restore hard and soft tissues. Further improvement of these therapies may involve more biological approaches and the use of dental tissue stem cells in combination with inorganic/organic scaffolds. In this study, we analyzed the osteoconductivity of two different inorganic scaffolds based on poly (lactic-co-glycolic) acid alone (PLGA-Fisiograft) or in combination with hydroxyapatite (PLGA/HA-Alos) in comparison with an organic material based on equine collagen (PARASORB Sombrero) both in vitro and in vivo. We developed a simple in vitro model in which periosteum-derived stem cells were grown in contact with chips of these scaffolds to mimic bone mineralization. The viability of cells and material osteoconductivity were evaluated by osteogenic gene expression and histological analyses at different time points. In addition, the capacity of scaffolds to improve bone healing in sinus lift was examined. Our results demonstrated that the osteoconductivity of PLGA/HA-Alos and the efficacy of scaffolds in promoting bone healing in the sinus lift were increased. Thus, new clinical approaches in sinus lift follow-up should be considered to elucidate the clinical potential of these two PLGA-based materials in dentistry.
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