毒蕈碱乙酰胆碱受体
受体
内吞循环
串扰
神经科学
乙酰胆碱
神经药理学
毒蕈碱乙酰胆碱受体M4
毒蕈碱乙酰胆碱受体M3
毒蕈碱乙酰胆碱受体M2
乙酰胆碱受体
生物
细胞生物学
药理学
内吞作用
生物化学
工程类
电子工程
作者
Dmitry Zenko,James N. Hislop
标识
DOI:10.1016/j.neuropharm.2017.11.017
摘要
Fidelity of signal transduction relies on cells expressing the appropriate number of functional receptors. Fluctuation in the total number of muscarinic acetylcholine receptors has been implicated in a range of physiological and pathophysiological processes, and the mechanisms responsible for this regulation represent potential molecular targets for therapeutic intervention. This article will review the current literature on the endocytic trafficking of muscarinic receptors and how knowledge of the trafficking of related receptors might influence future studies. This article is part of the Special Issue entitled ‘Neuropharmacology on Muscarinic Receptors’.
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