强直性脊柱炎
医学
骶髂关节炎
疾病
免疫学
发病机制
病理生理学
脊柱炎
HLA-B27
生物信息学
病理
人类白细胞抗原
生物
抗原
作者
Anoek de Koning,Jan W. Schoones,Désirée van der Heijde,F. van Gaalen
摘要
Abstract Background Axial spondyloarthritis (axSpA) is a common inflammatory arthritis of the sacroiliac joints and the spine. The best‐known and most studied form of axSpA is ankylosing spondylitis. Design In this review, we provide a brief overview of the pathophysiology of axSpA. In addition, we performed a quantitative text analysis of reviews on the pathogenesis of axSpA published in the last 10 years to establish the current consensus in various fields of research into the pathogenesis of axSpA. Results There appears to be broad consensus on genetic risk factors and the involvement of the immune system in the initiation phase of the disease although little consensus was found on which specific immune cells drive disease. Moreover, despite relatively little data available, alterations in the microbiome are commonly thought to be involved in disease. Abnormal bone formation is the most prominent pathogenic factor thought to be involved in disease progression. Conclusion So, although the pathophysiology of axSpA remains incompletely understood, the progress in recent years in several fields of research in axSpA including genetics, diagnosis, imaging and therapeutics, hold great promise for the future.
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