骨整合
材料科学
涂层
结晶度
钛
退火(玻璃)
润湿
超亲水性
微型多孔材料
纳米颗粒
生物相容性
纳米技术
生物医学工程
化学工程
复合材料
植入
冶金
医学
工程类
外科
作者
Long Bai,Zhibin Du,Jingjing Du,Weiqin Yao,Jiaming Zhang,Zeming Weng,Si Liu,Ya Zhao,Yanlian Liu,Xiangyu Zhang,Xiaobo Huang,Xiaohong Yao,Ross Crawford,Ruiqiang Hang,Di Huang,Bin Tang,Yin Xiao
出处
期刊:Biomaterials
[Elsevier]
日期:2018-04-01
卷期号:162: 154-169
被引量:213
标识
DOI:10.1016/j.biomaterials.2018.02.010
摘要
A multifaceted coating for hard tissue implants, with favorable osteogenesis, angiogenesis, and osteoimmunomodulation abilities, would be of great value since it could improve osseointegration and alleviate prosthesis loosening. However, to date there are few coatings that fully satisfy these criteria. Herein we describe a microporous TiO2 coating decorated with hydroxyapatite (HA) nanoparticles that is generated by micro-arc oxidation of pure titanium (Ti) and followed annealing. By altering the annealing temperature, it is possible to simultaneously tune the coating's physical (morphology and wettability) and chemical (composites and crystallinity) properties. A coating produced with micro-arc oxidization (MAO) with an annealing temperature of 650 °C (MAO-650) exhibits numerous favorable physicochemical properties, such as hybrid micro-nano morphology, superhydrophilicity, and highly crystalline HA nanoparticles. In vitro experiments reveal that the MAO-650 coating not only supports proliferation and differentiation of both osteoblasts and endothelial cells, but also inhibits the inflammatory response of macrophages and enables a favorable osteoimmunomodulation to facilitate osteo/angio-genesis. In vivo evaluation mirrors these results, and shows that the MAO-650 coating results in ameliorative osseointegration when compared with the pristine MAO coating. These data highlight the profound effect of surface physicochemical properties on the regulation of osteo/angio-genesis and osteoimmunomodulation in the enhancement of osseointegration.
科研通智能强力驱动
Strongly Powered by AbleSci AI