PBPK in Preterm and Term Neonates: A Review

Introduction: The neonatal population remains one of the populations in which appropriate dosing regimens are still lacking, resulting in a large off-label or unlicensed use. Clinical research in these small infants remains a challenge, which sparks the need for modeling and simulation as an additional tool for neonatal drug research. Keywords: PBPK, neonates, pharmacokinetics, retrograde approach, bottom-up approach, pediatric drug research.