硼烷
化学
电泳剂
非对映体
光学活性
烷基化
药物化学
作者
Nobuhiko Oohara,Tsuneo Imamoto
摘要
The reactivity of t-butylphosphine–borane toward various electrophiles was studied with a focus on alkylation. Monoalkylation of this compound proceeded smoothly in good yields (61–85%). Disubstituted derivatives were also synthesized in good yields (86–99%). Optically active t-butylmethylphosphine–borane was prepared from t-butylphosphine–borane by resolution of intermediate diastereomers of (1S)-endo-2-bornyloxycarbonyl(t-butyl)methylphosphine-borane.
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