化学
多米诺骨牌
对映选择合成
试剂
催化作用
基质(水族馆)
芳基
组合化学
范围(计算机科学)
有机化学
计算机科学
海洋学
地质学
程序设计语言
烷基
作者
Kuai Wang,Zhengtian Ding,Zhijun Zhou,Wangqing Kong
摘要
A Ni-catalyzed enantioselective reductive diarylation of activated alkenes by domino cyclizative/cross-coupling of two aryl bromides is developed. This reaction proceeds under very mild conditions and shows broad substrate scope, without requiring the use of preformed organometallic reagents. Moreover, this approach provides direct access to various bis-heterocycles bearing all-carbon quaternary centers in synthetically useful yields (up to 81%) with excellent enantioselectivity (>30 examples, 90-99% ee).
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