Single-center versus multicenter trials

Abstract This chapter provides a definition of single and multicenter trials and discusses a number of issues related to these two classes of trials. These include National Institutes of Health count of single center and multicenter trials, design characteristics of single center versus multicenter trials, the pros and cons of single center versus multicenter trials, initiation of single center versus multicenter trials, investigator incentives for single center versus multicenter trials, timing of incentives for single center versus multicenter trials, and cost of single center versus multicenter trials.