生物相容性
自愈水凝胶
壳聚糖
明胶
肿胀 的
3D生物打印
伤口愈合
材料科学
海藻酸钠
生物医学工程
傅里叶变换红外光谱
嫁接
生物相容性材料
组织工程
化学
核化学
化学工程
高分子化学
钠
复合材料
有机化学
外科
聚合物
医学
工程类
作者
Yueqi Lu,Jie Xu,Ya Su,Huan Fang,Jiaqi Liu,Shanshan Lv,Yuen Yee Cheng,Yi Nie,Wenfang Li,Bo Pan,Kedong Song
出处
期刊:International Journal of bioprinting
[Whioce Publishing Pte Ltd.]
日期:2023-02-20
卷期号:9 (2): 689-689
被引量:13
摘要
Severe skin injuries can cause serious problems, which could affect the patient’s normal life, if not dealt properly in a timely and effective manner. It is an urgent requirement to develop personalized wound dressings with excellent antibacterial activity and biocompatibility to match the shape of the wound to facilitate clinical application. In this study, a bioink (GAQ) based on gelatin (Gel)/sodium alginate (SA)/ quaternized chitosan (QCS) was prepared, and GAQ hydrogel dressing grafting with dopamine (GADQ) was fabricated by an extrusion three-dimensional (3D) printing technology. QCS was synthesized by modifying quaternary ammonium group on chitosan, and its structure was successfully characterized by nuclear magnetic resonance (1H NMR) and Fourier-transform infrared spectroscopy (FT-IR). Our results showed that the GADQ hydrogel dressing that was double-crosslinked by EDC/ NHS and Ca2+ had good tensile strength, considerable swelling ratio, and effective antioxidation properties. It also showed that GADQ1.5% had 93.17% and 91.06% antibacterial activity against Staphylococcus aureus and Escherichia coli, respectively. Furthermore, the relative survival ratios of fibroblast cells seeded on these hydrogels exceeded 350% after cultured for 7 days, which proved the biocompatibility of these hydrogels. Overall, this advanced 3D-printed GADQ1.5% hydrogels with effective antioxidation, excellent antibacterial activity and good biocompatibility had a considerable application potential for wound healing.
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