人类白细胞抗原
CD8型
生物
免疫学
细胞毒性T细胞
T细胞
病毒学
抗原
免疫系统
遗传学
体外
作者
Hongbing Yang,Hong Sun,Simon Brackenridge,Xiaodong Zhuang,Peter A. C. Wing,Max Quastel,Lucy C. Walters,Lee Garner,Beibei Wang,Xuan Yao,Suet Ling Felce,Yanchun Peng,Shona C. Moore,Bas W. A. Peeters,Margarida Rei,João Canto-Gomes,Ana Tomás,Andrew D. Davidson,Malcolm G. Semple,Lance Turtle
出处
期刊:Science immunology
[American Association for the Advancement of Science]
日期:2023-06-30
卷期号:8 (84)
被引量:14
标识
DOI:10.1126/sciimmunol.abl8881
摘要
Pathogen-specific CD8 + T cell responses restricted by the nonpolymorphic nonclassical class Ib molecule human leukocyte antigen E (HLA-E) are rarely reported in viral infections. The natural HLA-E ligand is a signal peptide derived from classical class Ia HLA molecules that interact with the NKG2/CD94 receptors to regulate natural killer cell functions, but pathogen-derived peptides can also be presented by HLA-E. Here, we describe five peptides from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that elicited HLA-E–restricted CD8 + T cell responses in convalescent patients with coronavirus disease 2019. These T cell responses were identified in the blood at frequencies similar to those reported for classical HLA-Ia–restricted anti–SARS-CoV-2 CD8 + T cells. HLA-E peptide–specific CD8 + T cell clones, which expressed diverse T cell receptors, suppressed SARS-CoV-2 replication in Calu-3 human lung epithelial cells. SARS-CoV-2 infection markedly down-regulated classical HLA class I expression in Calu-3 cells and primary reconstituted human airway epithelial cells, whereas HLA-E expression was not affected, enabling T cell recognition. Thus, HLA-E–restricted T cells could contribute to the control of SARS-CoV-2 infection alongside classical T cells.
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