自愈水凝胶
丙烯酰胺
共聚物
药物输送
化学
化学工程
热稳定性
高分子化学
极限抗拉强度
组织工程
材料科学
聚合物
有机化学
生物医学工程
复合材料
工程类
医学
作者
Yan‐Yan Hu,Younghyun Shin,Sohyun Park,Jaepil Jeong,Young S. Kim,Seunho Jung
出处
期刊:Polymers
[MDPI AG]
日期:2022-12-28
卷期号:15 (1): 122-122
被引量:6
标识
DOI:10.3390/polym15010122
摘要
We prepared the self-healing and temperature/pH-responsive hydrogels using oxidized succinoglycan (OSG) and a poly (N-isopropyl acrylamide-co-acrylamide) [P(NIPAM-AM)] copolymer. OSG was synthesized by periodate oxidation of succinoglycan (SG) isolated directly from soil microorganisms, Sinorhizobium meliloti Rm1021. The OSG/P(NIPAM-AM) hydrogels were obtained by introducing OSG into P(NIPAM-AM) networks. The chemical structure and physical properties of these hydrogels were characterized by ATR-FTIR, XRD, TGA, and FE-SEM. The OSG/P(NIPAM-AM) hydrogels showed improved elasticity, increased thermal stability, new self-healing ability, and 4-fold enhanced tensile strength compared with the P(NIPAM-AM) hydrogels. Furthermore, the 5-FU-loaded OSG/P(NIPAM-AM) hydrogels exhibited effective temperature/pH-responsive drug release. Cytotoxicity experiments showed that the OSG/P(NIPAM-AM) hydrogels were non-toxic, suggesting that OSG/P(NIPAM-AM) hydrogels could have the potential for biomedical applications, such as stimuli-responsive drug delivery systems, wound healing, smart scaffolds, and tissue engineering.
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