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Biomarkers of intestinal permeability and blood-brain barrier permeability in adolescents with major depressive disorder

重性抑郁障碍 肠道通透性 焦虑 血脑屏障 内科学 医学 哈姆德 萧条(经济学) 心理学 精神科 中枢神经系统 宏观经济学 经济 扁桃形结构
作者
Hongyan Wu,Jie Wang,Teng Teng,Bangmin Yin,Yuqian He,Yuanliang Jiang,Xueer Liu,Ying Yu,Xuemei Li,Xinyu Zhou
出处
期刊:Journal of Affective Disorders [Elsevier BV]
卷期号:323: 659-666 被引量:40
标识
DOI:10.1016/j.jad.2022.11.058
摘要

The etiology in major depressive disorder (MDD) has not been fully understood. Accumulating evidence suggests an association between altered intestinal and blood-brain barrier (BBB) permeability and psychiatric disorders, while its changes in adolescent MDD populations have been received less attention. In this study, our aim was to explore the differences in plasma levels of intestinal and blood-brain barrier permeability markers in adolescents with MDD compared with healthy controls (HCs).We enrolled MDD (n = 50), and HCs (n = 40) with the age of 13-18 years old. The plasma level of zonulin, I-FABP, LPS, and claudin-5 were quantified. The Hamilton Depression Scale 17 items (HAMD-17) and Hamilton Anxiety Scale 14 items (HAMA-14) were used for symptom assessments.The plasma levels of zonulin, I-FABP, LPS, and claudin-5 in the MDD group were significantly higher than those in the HCs. Plasma I-FABP levels in MDD with moderate to severe anxiety were significantly higher than those in MDD without moderate to severe anxiety and HCs. In addition, these four biomarkers (alone or combined) can be used as diagnostic markers for MDD in adolescents.The key limitation of this study is the blood measurements at a single time point with a relatively small sample size.These findings advance our understanding of the pathophysiology of intestinal barrier injury, bacterial translocation, and blood-brain barrier injury involved in adolescents with MDD.
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