白色念珠菌
癌症
白色体
生物
免疫系统
癌细胞
免疫学
微生物学
癌症研究
遗传学
作者
Xu Wang,Wenqing Zhang,Wenjie Wu,Shuangshuang Wu,Andrew Young,Yan Zhang
标识
DOI:10.1016/j.micres.2023.127370
摘要
The association between Candida albicans (C. albicans) and cancer has been noticed for decades. Whether C. albicans infection is a complication of cancer status or as a contributor to cancer development remains to be discussed. This review systematically summarized the up-to-date knowledge about associations between C. albicans and various types of cancer, and discussed the role of C. albicans in cancer development. Most of the current clinical and animal evidence support the relationship between C. albicans and oral cancer development. However, there is insufficient evidence to demonstrate the role of C. albicans in other types of cancer. Moreover, this review explored the underlying mechanisms for C. albicans promoting cancer. It was hypothesized that C. albicans may promote cancer progression by producing carcinogenic metabolites, inducing chronic inflammation, remodeling immune microenvironment, activating pro-cancer signals, and synergizing with bacteria.
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