上睑下垂
化学
细胞凋亡
肝损伤
毒性
TLR4型
CYP2E1
药理学
氧化应激
MAPK/ERK通路
信号转导
生物化学
医学
体外
程序性细胞死亡
内科学
微粒体
作者
Hongming Lv,Jiahe Liu,Yuxi He,Shijie Xia,Chunyu Qiao,Chuang Xu
标识
DOI:10.1021/acs.jafc.3c05776
摘要
-induced hepatotoxic effects and its main mechanism involved the inhibitory effects on oxidative stress, apoptosis, liver fibrosis, inflammation, and pyroptosis, which might be partially dependent on the regulation of Nrf2. The work may enrich the role and mechanism of Lico A's resistance to liver injury caused by various factors, and its application is promising.
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