肥胖
混淆
超重
脂类学
内科学
溶血磷脂酰胆碱
医学
体质指数
内分泌学
生理学
生物信息学
生物
生物化学
磷脂
膜
磷脂酰胆碱
作者
Sapna Sharma,Y. V. B. K. Subrahmanyam,Harish Ranjani,Sidra Sidra,Dharmeshkumar Parmar,Sangeetha Vadivel,Shanthini Kannan,Harald Grallert,Dandamudi Usharani,Ranjit Mohan Anjana,Muthuswamy Balasubramanyam,Viswanathan Mohan,Adamski Jerzy,Venkateswarlu Panchagnula,Kuppan Gokulakrishnan
标识
DOI:10.1016/j.numecd.2024.02.009
摘要
Obesity has reached epidemic proportions, emphasizing the importance of reliable biomarkers for detecting early metabolic alterations and enabling early preventative interventions. However, our understanding of the molecular mechanisms and specific lipid species associated with childhood obesity remains limited. Therefore, the aim of this study was to investigate plasma lipidomic signatures as potential biomarkers for adolescent obesity.A total of 103 individuals comprising overweight/obese (n = 46) and normal weight (n = 57) were randomly chosen from the baseline ORANGE (Obesity Reduction and Noncommunicable Disease Awareness through Group Education) cohort, having been followed up for a median of 7.1 years. Plasma lipidomic profiling was performed using the UHPLC-HRMS method. We used three different models adjusted for clinical covariates to analyze the data. Clustering methods were used to define metabotypes, which allowed for the stratification of subjects into subgroups with similar clinical and metabolic profiles. We observed that lysophosphatidylcholine (LPC) species like LPC.16.0, LPC.18.3, LPC.18.1, and LPC.20.3 were significantly (p < 0.05) associated with baseline and follow-up BMI in adolescent obesity. The association of LPC species with BMI remained consistently significant even after adjusting for potential confounders. Moreover, applying metabotyping using hierarchical clustering provided insights into the metabolic heterogeneity within the normal and obese groups, distinguishing metabolically healthy individuals from those with unhealthy metabolic profiles.The specific LPC levels were found to be altered and increased in childhood obesity, particularly during the follow-up. These findings suggest that LPC species hold promise as potential biomarkers of obesity in adolescents, including healthy and unhealthy metabolic profiles.
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