脚手架
细胞外基质
清除
再生(生物学)
材料科学
基质(化学分析)
细胞生物学
纳米技术
生物物理学
化学
生物医学工程
复合材料
抗氧化剂
生物化学
生物
医学
作者
Zhiqing Liu,Tianlong Wang,Lei Zhang,Yiping Luo,Jinhui Zhao,Yixing Chen,Yao Wang,Weiguo Cao,Xinyu Zhao,Bing‐Qiang Lu,Feng Chen,Zifei Zhou,Longpo Zheng
标识
DOI:10.1002/adhm.202304158
摘要
Abstract The limited regulation strategies of the regeneration microenvironment significantly hinder bone defect repair effectiveness. One potential solution is using biomaterials capable of releasing bioactive ions and biomolecules. However, most existing biomaterials lack real‐time control features, failing to meet high regulation requirements. Herein, a new Strontium (Sr) and epigallocatechin‐3‐gallate (EGCG) based metal–phenolic network with polydopamine (PMPNs) modification was prepared. This material reinforces a biomimetic scaffold made of extracellular matrix (ECM) and hydroxyapatite nanowires (nHAW). The PMPNs@ECM/nHAW scaffold demonstrated exceptional scavenging of free radicals and ROS, promoting HUVECs cell migration and angiogenesis, inducing stem cell osteogenic differentiation, and displaying high biocompatibility. Additionally, the PMPNs exhibited excellent photothermal properties, further enhancing the scaffold's bioactivities. In vivo studies confirmed that PMPNs@ECM/nHAW with NIR stimulation significantly promoted angiogenesis and osteogenesis, effectively regulating the microenvironment and facilitating bone tissue repair. This research not only provides a biomimetic scaffold for bone regeneration but also introduces a novel strategy for designing advanced biomaterials. The combination of real‐time photothermal intervention and long‐term chemical intervention, achieved through the release of bioactive molecules/ions, represents a promising direction for future biomaterial development. This article is protected by copyright. All rights reserved
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