胰腺癌
肿瘤微环境
免疫系统
癌症研究
生物
细胞
癌症
癌细胞
免疫学
生物化学
遗传学
作者
Bolun Ai,Yicheng Liang,Tao Yan,Yangyang Lei
摘要
Abstract Clinical outcomes remain unsatisfactory in patients with pancreatic cancer (PAC). In this study, through single‐cell sequencing, we identified eight cell subpopulations in the tumor microenvironment (TME). Redimensional clustering of epithelial cells, myeloid cells, and cancer‐associated fibroblasts (CAFs) revealed heterogeneity in the TME of PAC. Intercellular communication analysis showed strong direct interactions between matrix CAFs, inflammatory CAFs, and epithelial cells. Additionally, we found that the SPP1‐associated pathway was activated in monocytes, whereas the vascular endothelial growth factor‐associated pathway was activated in epithelial cells. These results improve the understanding of the TME of pancreatic cancer and provide a foundation for further studies on intratumoral heterogeneity. In addition, differentially expressed gene secretory leukocyte protease inhibitor (SLPI) was identified in pancreatic cancer, and functional experiments showed that SLPI had a strong impact on cell viability and apoptosis, which offers a potential therapy target for pancreatic cancer.
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