免疫学
疾病
类风湿性关节炎
强直性脊柱炎
多发性硬化
自身免疫性疾病
医学
发病机制
实验性自身免疫性脑脊髓炎
机制(生物学)
微嵌合体
免疫系统
自身免疫
抗体
生物
病理
遗传学
怀孕
哲学
胎儿
认识论
作者
Jiantao Sun,Lujuan Huang,Jiawei Wang,Yelang Hu,Wenmin Wang,Haihong Zhu
出处
期刊:Annales De Biologie Clinique
[John Libbey Eurotext]
日期:2024-02-01
卷期号:82 (1): 33-42
被引量:4
标识
DOI:10.1684/abc.2024.1866
摘要
Ferroptosis is an iron dependent cell death driven by lipid peroxidation. Over the past decade, increasing evidence has confirmed that ferroptosis plays an irreplaceable role in the occurrence and development of many diseases, including various cancers, neurodegenerative diseases, cardiovascular diseases and autoimmune diseases. Autoimmune disease is an inflammatory disease characterized by the breakdown of immune tolerance. Nowadays, accumulating evidence indicates that ferroptosis is closely related to the pathogenesis of autoimmune diseases. Therefore, this review briefly introduced the mechanism of ferroptosis, and focused on the related research of ferroptosis in multiple autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), ankylosing spondylitis (AS). In addition, we also presented the idea of targeting ferroptosis as a potential therapeutic target for patients with autoimmune diseases, which may provide a direction for the development of new therapeutic strategies.
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