化学
废止
阿齐林
立体化学
有机化学
催化作用
戒指(化学)
作者
Lesong Li,Zhenyu Shi,Congyang Li,Xiaoli Zhang,Yichi Zhang,Weiwu Ren,Weiwu Ren
标识
DOI:10.1021/acs.joc.4c00654
摘要
NHC-catalyzed [4+2] annulation of 2H-azirine-2-carbaldehydes with ketimines and isocyanates has been developed, providing straightforward synthetic protocols for constructing structurally intriguing pyrimido[1,2-a]indolediones and pyrimidinediones under mild conditions with excellent yields. This protocol can be used to synthesize the core skeleton of pharmaceutically important drugs and pyrimido[1,2-a]indoledione-containing natural products, making it potentially valuable for creating biologically active derivatives.
科研通智能强力驱动
Strongly Powered by AbleSci AI