药物输送
细胞外小泡
胞外囊泡
药品
癌症
免疫疗法
放射治疗
医学
免疫原性
癌症治疗
纳米技术
药理学
微泡
免疫系统
免疫学
生物
材料科学
内科学
细胞生物学
小RNA
生物化学
基因
作者
Zhenggang Wang,Haokun Mo,Zishu He,Anmin Chen,Peng Cheng
标识
DOI:10.1016/j.biopha.2022.113480
摘要
Cancer is one of the primary causes of death worldwide, and its morbidity and mortality rates are increasing rapidly. However, standard treatment modalities (surgery, radiotherapy, chemotherapy, and immunotherapy) often fail to achieve a satisfactory therapeutic effect. Extracellular vesicles (EVs) are natural nano-sized lipid bilayer vesicles secreted from cells. Owing to their advantages of low toxicity, high biocompatibility, low immunogenicity, and inherent targeting, EVs can be exploited as drug delivery vectors for cancer treatment. In this review, we summarize the research progress of EV-based drug delivery systems in cancer treatment by focusing on four aspects: sources, cargo types, cargo loading methods and modification strategies. Finally, current challenges and future perspectives are discussed.
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