介孔材料
吸附
萃取(化学)
材料科学
色谱法
固相萃取
硼酸
比表面积
选择性
化学工程
化学
有机化学
催化作用
工程类
作者
Yifeng Xu,Yuzhu Sun,Zewei Yao,Yinmao Wei
标识
DOI:10.1021/acsami.3c05025
摘要
In this work, a boronate affinity-functionalized hierarchical mesoporous metal–organic framework adsorbent with boronate sites only in the small mesopore has been structured based on UiO-66@Fe3O4. The introduction of large mesopores in the adsorbent can promote the diffusion of small cis-diol-containing compounds (cis-diols) into small mesopore channels, and the removal of the adsorption sites on the external surface of materials and in large mesopores can enhance the size-exclusion effect of the adsorbent. In addition, the adsorbent has faster adsorption kinetics and excellent selectivity to small cis-diols. Finally, a magnetic dispersive solid-phase extraction coupled with high-performance liquid chromatography was established for the enrichment and detection of nucleotides in plasma. Four nucleotides achieve the recoveries from 93.25 to 118.79%, the limits of detection from 0.35 to 1.26 ng·mL–1, and the intra-day and inter-day relative standard deviations of less than 10.2%. In conclusion, this method can be directly used for the detection of small cis-diol targets in complex biological samples without protein precipitation prior to the extraction.
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