Aiming at the problems that teaching laboratories in colleges and universities mainly rely on the management of experimental teachers, that there are few people and more experimental rooms, and that the management methods and access methods are relatively complicated, a smart laboratory management system based on the Internet of Things is designed. The system is divided into the terminal control system of the lower computer and the cloud management system of the upper computer. The lower computer, with the STM32 single-chip microcomputer as the core, uses RFID radio frequency technology, NB-IoT and electromagnetic lock module to realize the personnel identification information transmission. The upper computer establishes the interaction between the Internet of Things platform based on the cloud server and the WeChat applet, and realizes the application for personnel to enter and exit the laboratory, the approval of the administrator and the recording, Finally, the intelligent management of the laboratory is realized.