31P Nuclear Magnetic Resonance Spectroscopy for Monitoring Organic Reactions and Organic Compounds

Abstract 31 P NMR spectroscopy is a consolidated tool for the characterization of organophosphorus compounds and, more recently, for reaction monitoring. The evolution of organic synthesis, mainly due to the combination of elaborated building blocks with enabling technologies, generated great challenges to understand and to optimize the synthetic methodologies. In this sense, 31 P NMR experiments also became a routine technique for reaction monitoring, accessing products and side products yields, chiral recognition, kinetic data, intermediates, as well as basic organic parameters, such as acid‐base and hydrogen‐bonding. This review deals with these aspects demonstrating the essential role of the 31 P NMR spectroscopy. The recent publications (the last ten years) will be explored, discussing the experiments of 31 P NMR and the strategies accomplished to detect and/or quantify distinct organophosphorus molecules, approaching reaction mechanism, stability, stereochemistry, and the utility as a probe.